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KMID : 1123920060200051282
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 5 p.1282 ~ p.1284
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Hepatoprotective Lignan Compound from Schizandrae Fructus on Tacrine-induced Cytotoxicity in Hep G2 Cells
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Kim Hyun-Chul
An Ren-Bo
Jeong Gill-Saeng
Bum Jin-Sun
Oh Seung-Hwan
Lee Hye-Suk
Kwon Ji-Wung
Kwon Tae-Oh
Kim Youn-Chul
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Abstract
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In the course of search for hepatoprotective agents from oriental traditional medicines, one compound was isolated from the MeOH extract of the fruits of Schizandra chinensis, and its structure was determined as gomisin J(1). The evaluation for hepatoprotective activity of isolated compound 1 on drug-induced cytotoxicity was conducted, and compound 1 showed protective effect with an ECvalue of 86.0 5.3 M against tacrine-induced cytotoxicity in Hep G2 cells. One of the well-known hepatoprotective agents, silybin, used as a positive control, and the hepatoprotective effect of compound 1 is similar with that of silybin (EC value = 90.5 9.8 M).
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KEYWORD
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Schizandrae Fructus, Lignan, Gomisin J, Hepatoprotective, Tacrine, Hep G2
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